“Overall, saffron presents as a promising natural option for the treatment of mild-to-moderate depression with initial clinical research … The research evidence is promising, with many studies outlining that in particular the stigma of a saffron plant and its petals can have a positive effect on mood, and that saffron can be extremely effective in treating depression and anxiety, perhaps more effective than many users would initially dare to hope.. Studies on animals fore example have shown that it may have an anti … Saffron is a spice with a distinct taste and aroma. ... it is too early to recommend it for treating depression symptoms. Depression and anxiety impose high economic and social costs. • As a nootropic, Saffron has been used for thousands of years as an anxiolytic, sedative, and antidepressant. Phytotherapy, using scientific methods to determine appropriate and effective medicinal use of plant-derived medications, is of particular interest to integrative providers. Saffron is the dried stigma of the Crocus sativus plant native to the Middle East. • Antidepressant efficacy of saffron and crocin is comparable to those of standard drugs. I now use daily and intend to for the rest of my life. SYNOPSIS: Saffron studies, while still preliminary, show potential for use of this ancient spice in combatting mild-moderate depression. Objective: This systematic review and meta-analysis sought to investigate the effect of saffron supplementation, as both an adjunctive therapy and monotherapy, on symptoms of depression and anxiety in clinical and general populations compared with pharmacotherapy or placebo. [i] Today, Saffron is used to help manage appetite, for … Saffron - A powerful Natural Anti-depressant Several interesting clinical studies have reported the antidepressant and anti-anxiety properties of Saffron, the dried stigmas of Crocus sativus. Promoting libido. Read more about this medicinal plant below. 1 With recent studies showing promising results, saffron, from … The spice saffron was as effective as the antidepressants fluoxetine and imipramine in reducing symptoms of mild-to-moderate depression in adults, according to a meta-analysis published in Human Psychopharmacology. And is the world’s most expensive culinary spice largely due to the way it must be grown and harvested (by hand). However, research is ongoing, and larger, longer studies are needed … After about 3 years, I took a 4 week break from Saffron and had a relapse into depression. Saffron supplements show promise as a natural treatment for depression. These studies have demonstrated saffron and its active constituents possess antidepressant properties similar to current antidepressant medications such as fluoxetine, … • Clinical findings have shown that saffron and its active constituents possess antidepressant properties. 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